Accession Number: ATLA0001712150; Hosting Book Page Citation: p 236-252.; Language(s): English; General Note: Bibliography: p 250-252.; Issued by ATLA: 20130825; Publication Type: Essay.

Interferon (IFN) induced during a virus infection mediates antiviral effects both by direct inhibition of virus replication and by influencing the proliferation, differentiation, and chemotaxis of cyto‐toxic lymphocytes which control the infection. Cells from tissue taken from virus‐infected mice are conditioned by IFN to resist lysis by natural killer (NK) cells, while they become increasingly susceptible to lysis by cytotoxic Tlymphocytes (CTL). This is due to marked IFN‐induced biochemical changes, including an up‐regulation of major histocompatibility antigens, which are targets for (...) CTL. Cytopathic viruses, which inhibit cellular RNA and protein synthesis, render target cells refractory to IFN‐mediated protection against NK cells, thereby providing a mechanism for NK cells to mediate antiviral effect by preferentially lysing virus‐infected but not uninfected cells. (shrink)

Two experiments were conducted with variants of Wason's (1966) selection task. The common focus was the effect of differences in the sizes of the sets represented by P and not-Q in assertions of the form _If P then Q_ (conditional) or _All P are Q_ (categorical). Results support the conclusion that such set size differences affect the strategies people adopt when asked to determine, efficiently, the truth or falsity of such assertions, but they do not entirely negate the tendency to (...) select the term represented by P (the antecedent of the conditional or the subject of the categorical) in preference to the term represented by not-Q (the complement of the consequent of the conditional or the complement of the predicate of the categorical). Several possible explanations of this perseverance are considered. Results also support the conclusion that people find it easier to assess categorical assertions than logically equivalent conditional assertions. (shrink)

The "two-envelopes" problem has stimulated much discussion on probabilistic reasoning, but relatively little experimentation. The problem specifies two identical envelopes, one of which contains twice as much money as the other. You are given one of the envelopes and the option of keeping it or trading for the other envelope. Variables of interest include the possible amounts of money involved, what is known about the process by which the amounts of money were assigned to the envelopes, and whether you are (...) allowed to know how much money is in the envelope in hand before deciding whether to keep or trade. In an earlier study, Butler and Nickerson found that when participants were allowed to know how much was in the envelope in hand, they generally elected to trade if that amount was small relative to the range of possibilities and to keep otherwise. The present experiments showed that this propensity was independent of the amount of money in the envelopes. Participants made decisions with a strong bias for avoiding the risk of losing by trading, particularly when the amount in hand was known and large relative to the range of possible amounts, regardless of the absolute value of the gamble. The results illustrate the dependence of thinking on the context in which it occurs, and demonstrate a tendency to treat quantities that are large or small relative to a particular context in which they are encountered as though they were large or small in a more general sense. (shrink)

ABSTRACTTreating conditionals as probabilistic statements has been referred to as a defining feature of the “new paradigm” in cognitive psychology. Doing so is attractive for several reasons, but it complicates the problem of assessing the merits of conditional arguments. We consider several variables that relate to judging the persuasiveness of conditional arguments with uncertain premises. We also explore ways of judging the consistency of people's beliefs as represented by components of conditional arguments. Experimental results provide evidence that inconsistencies in beliefs (...) are more prevalent if the arguments’ components are spatially and temporally dispersed than if they are contiguous in space and time. This supports the idea that assuring the consistency among even a small number of beliefs is difficult to do, especially if the beliefs in question are not brought into consciousness at the same time; but consistency can be enhanced when beliefs are considered simultaneously or nea... (shrink)

Participants attempted to solve a modified version of Wason's selection task. Variables were: sizes of the sets referenced by a specified assertion, form of the assertion, thematic content of the assertion, and the need for sampling or not. In Experiment 1, participants were given enough information to determine the truth or falsity of the specified assertion with certainty; in Experiment 2, they had to rely on sampling and could not determine the assertion's truth or falsity with certainty. Performance was better (...) in Experiment 1 than in Experiment 2, but in both cases much better than what is typically obtained with the conventional selection task. The results support the hypothesis that performance of the selection task is sensitive to the sizes of the sets involved, add credence to the conclusion that framing the task in a thematically meaningful way can facilitate performance, and demonstrate that facilitation does not require deontic reasoning or a well-known convention being involved. The relationship between expressed confidence and level of performance is consistent with other studies showing the former to be a good predictor of the latter. (shrink)

Daydreaming appears to have a complex relationship with life satisfaction and happiness. Here we demonstrate that the facets of daydreaming that predict life satisfaction differ between men and women , that the content of daydreams tends to be social others , and that who we daydream about influences the relation between daydreaming and happiness variables like life satisfaction, loneliness, and perceived social support . Specifically, daydreaming about people not close to us predicts more loneliness and less perceived social support, whereas (...) daydreaming about close others predicts greater life satisfaction. Importantly, these patterns hold even when actual social network depth and breadth are statistically controlled, although these associations tend to be small in magnitude. Individual differences and the content of daydreams are thus important to consider when examining how happiness relates to spontaneous thoughts. (shrink)

We applaud Ray and Cooper (2024) for emphasizing environmental health as a bioethics issue. As a team of interdisciplinary pediatric researchers and providers who are part of an institutional clima...

The “exchange paradox”—also referred to in the literature by a variety of other names, notably the “two-envelopes problem”—is notoriously difficult, and experts are not all agreed as to its resolution. Some of the various expressions of the problem are open to more than one interpretation; some are stated in such a way that assumptions are required in order to fill in missing information that is essential to any resolution. In three experiments several versions of the problem were used, in each (...) of which the information given was sufficient to determine an optimal choice strategy when it exists or to justify indifference regarding keeping or trading when such a strategy does not exist. College students who were presented with the various versions of the problem tended to base their choices on simple heuristics and to give little evidence of understanding the probabilistic implications of the differences in the problem statements. (shrink)

First published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

From the point of view of a saint's life, the article addresses the question of integrating holiness and business dealings. By analyzing the heavy involvement of Vincent de Paul, a seventeenth century French saint, in the world of finance and politics as he ministered to the poor of his day, the study attempts to show that it is both possible and beneficial to join together the world of business with that of a religiously inspired ethic. The spiritually grounded manner in (...) which Vincent de Paul approached his institutional tasks and the ways in which those endeavors gave body to his spirituality present an unitary, non-dualistic instance of how business and morality can interact. (shrink)

In this book Michael McKenna advances a new theory of moral responsibility, one that builds upon the work of P.F. Strawson.